Rating of the best sartans for 2020

Most people over the age of 30 have some kind of health problem. Most often, problems with the cardiovascular system are in the lead among them. They arise due to improper lifestyle - lack of physical activity, unhealthy diet, excess weight, lack of sleep, etc. One of the main disorders is increased blood pressure, which is also called hypertension. A large number of medications are sold to treat this condition, which have many side effects.

As medical science is constantly improving, a large number of new drugs are constantly being developed. Among the novelties of this kind, one can distinguish sartans - a group of substances that lower blood pressure by reducing the susceptibility of the sensitive elements of the endothelium in the cardiovascular system to AT 2 (angiotensin 2 is a substance that forces the walls of blood vessels to contract to increase blood pressure). These drugs were invented in order to reduce the side effects of previously used drugs, as well as restore the lost human health. We will consider the useful properties of these tablets below.

In this article, we will tell you what sartans are and what they are for, find out what to look for in order not to make mistakes when choosing, and learn about the benefits and dangers of these medicines, make a rating of high-quality drugs against pressure of the latest generation.

Indications for use

This drug is prescribed in the following cases:

• High blood pressure - in most cases, doctors prescribe this group in the presence of a second stage of the disease or more, since active substances have a pronounced effectiveness, and therefore can lower blood pressure to critical values, which is why uncontrolled use can lead to unpleasant consequences ...
• As a substitute for ACE inhibitors, when the patient cannot use this group of drugs. It can be used for both primary and secondary arterial pressure.
• With chronic heart failure. This therapy is indicated for both men and women.
• If the patient has a tendency to damage other organs, for example, the organs of vision. Blockers with cell protection function can slow down the process of tissue destruction and degeneration.
• For prolonging the life of patients who have suffered myocardial infarction. The functional of sartans ensures the acceleration of metabolism between cells and its stabilization, having a positive effect on the general condition of the body.

Useful properties of sartans

First of all, these substances are able to lower blood pressure, thereby improving blood circulation, relieving unpleasant symptoms and dangerous conditions of the body.

In addition, they can deny the following action:

• Improving the general condition of the heart muscle - reducing the load on the myocardium, thereby preventing the occurrence of a rapid heartbeat, as well as atrial fibrillation.
• A positive effect on the functioning of the brain - improving memory functions, accelerating thought processes, reducing the intensity and frequency of headaches, preventing the likelihood of a cerebral stroke.
• Improving the functioning of the excretory system, including the kidneys - reducing edema, leveling the mineral balance, etc.
• Improving metabolism - reducing the proportion of harmful cholesterol produced, increasing vascular permeability, improving the general condition of the body in diabetes (especially type II).

It should be noted that a positive result is observed only in those patients who take the drug for a long time. In the case of a single use, only a decrease in the level of blood pressure appears.

Doctors note the following advantages of this group - a small list of contraindications, a long period of excretion from the body, in connection with which you can take only 1 tablet per day, a low probability of side effects, can be used by elderly people, as well as those with serious health disorders, including including diabetes. According to the studies, sartans extend the life expectancy of patients with cardiovascular diseases by tens of years, reduce the risk of stroke, do not have such serious consequences as an increase in the likelihood of cancer (which is noted in analogues).

Dangerous properties of sartans

It should be noted that sartans, like any drug, have certain contraindications and cannot be used in the following cases:

• It is categorically impossible to apply the medicine to patients who have hypersensitivity to any component that is part of it. Uncontrolled use can cause allergic reactions, up to anaphylactic shock.
• It is also forbidden to use this substance for women during pregnancy and breastfeeding. Due to the lack of necessary research, it is not recommended to drink these tablets also for women who are of childbearing age and are not reliably protected due to the potential for pregnancy, and there is information in the scientific literature that the components of sartans can have a negative impact on the fetus. If conception has occurred, you must immediately stop taking the drug.
• The medicine is prescribed with caution to children, persons with identified insufficiency of circulating blood, with kidney diseases, including renal failure, cirrhosis of the liver, problems in the work of the biliary tract.
• Also, when sartans are co-administered with drugs that retain potassium in the body, their compatibility should be assessed.

Rating of the best sartans

Depending on what active substance is used in the drug, the following varieties are distinguished: tetrazole derivatives - biphenyl, non-heterocyclic and non-biphenyl. There is also another group that includes the latest developments in the field of medical science - these are the latest generation of non-phynyl tetrazole derivatives.

Biphenyl derivatives of tetrazole

Candesartan

The release form of the drug is tablets of 8, 16, and 32 milligrams. The active ingredient is cileksicil canderastan, the auxiliary substances are cellulose, starch, lactose, magnesium stearate, etc. The receptor blocker constricts blood vessels, stimulates water balance.After about 2 hours, a therapeutic result appears. The pressure decreases smoothly, without sudden jumps. The duration of the receptor blocker is a day or more. For a pronounced result, it is recommended to take the tablets for a long period (at least 1 month).

Studies have shown that people with chronic heart failure experience a reduction in hospitalizations and deaths due to the crisis with continued use. Sartans of this group can be drunk at any time of the day, regardless of food and drink. The drug is excreted through the kidneys and choleretic system. It does not accumulate in the body and is excreted unchanged. The initial dose is 8 mg per day, no adjustment is required for the elderly. For those diagnosed with impaired liver or kidney function, start with 4 mg. There are not many contraindications and side effects of the tablets, the main ones are weakness, nausea, and allergic reactions. It is not recommended to prescribe a blocker to children under 18 years of age, women during pregnancy and breastfeeding, with severe impaired liver and kidney function, as well as those who are sensitive to any component of the drug. The product is sold under the trade marks: Gypsokart, Ksarten, Atakand, etc. The average price of a package is about 300 rubles.

• can be consumed regardless of food intake;
• fast and visible result;
• smooth decrease in pressure.

• not suitable for children, as well as persons with diabetes mellitus, severely impaired liver and kidney function.

Losartan

The review continues with a remedy based on losartan potassium. There are two main brands of the drug on sale - Losartan and Lozap. The first one is about 2.5 times cheaper than the second one. This is due to the manufacturer, as well as to the degree of purification of the starting material. Release form - tablets. According to customer reviews, they are small in size and have a bitter taste, so it is recommended to drink them with plenty of water.

The package contains instructions for use with a detailed description of the pharmacological properties, side effects, precautions and contraindications. The list of contraindications is large, the main ones are pregnancy and breastfeeding, childhood, hypersensitivity to any component that is part of the tablets.

You need to take only 1 tablet per day with plenty of water, regardless of the meal. According to buyers, the action of Losartan is cumulative, a visible result appears several weeks after the start of use. According to the advice of buyers who use these tablets for a year or more, there is no need to overpay for a more expensive analogue, since the budget Losartan works no worse. In Russia, the well-known company OZON is engaged in the manufacture of the drug, and it can be ordered online in an online store at an order of magnitude cheaper than in a pharmacy. For a blister of 50 pieces, you will have to pay about 50 rubles, a package of 100 pieces costs 85 rubles.

• inexpensive in price, which is the main selection criterion for most Russians;
• visible result;
• smooth pressure drop;
• buyers do not have any problems with where to buy packaging - there is an opportunity to order delivery to any city through a branded online store of a Russian manufacturer.

• bitter taste of tablets;
• some buyers report side effects some time after use.

Irbesartan

The main active ingredient of the tablets is irbesartan hydrochloride. The drug is available in 3 different types of packaging - blisters of 75 mg, 150 mg, 300 mg. The pressure receptor blocker performs its main function, while it does not affect the concentration of uric acid, glucose and cholesterol in the body.It has shown itself best of all in the treatment of chronic heart and renal failure.

The maximum concentration in the blood occurs after 2 hours, the effect lasts for a day or more. A visible improvement occurs a week after the start of use. Half-life is observed after 15 hours, the components are excreted unchanged, mainly through the kidneys. No accumulation was found. The list of contraindications is small, in comparison with those of such drugs - childhood, allergic reactions, pregnancy and breastfeeding.

Patients note the following side effects: nausea, weakness, dizziness, tachycardia, cough, allergic reactions. To ensure a therapeutic result, it is enough to take one tablet a day, regardless of the meal. In case of an overdose, tachycardia or bradycardia may appear, as well as a decrease in blood pressure to critical values. The tablets are sold by prescription only. According to customer reviews, the treatment is easily tolerated, side effects are rare. Compared with Valsartan, the result is more pronounced and long-term. The average price of a package is 550 rubles.

• a small number of contraindications and side effects, dry cough does not appear, than the drug compares favorably with by-catch;
• you can take only one tablet per day;
• can be used for diabetics.

• high price.

Non-heterocyclic tetrazole derivatives

Valsartan

The main purpose of the substance is the treatment of arterial hypertension, as well as chronic heart failure. The active ingredient selectively blocks receptors that are responsible for increasing pressure, while not inhibiting ACE.

The first effect appears already after 2 hours after use, the maximum effectiveness is revealed after 4-5 hours. The active components are rapidly absorbed and excreted from the gastrointestinal tract unchanged. The concentrations of the active substance in the female and male body are equal. The drug is rapidly absorbed in the gastrointestinal tract, excreted in the following ratio - 70% with feces, 30% with urine. The first effect of the intake begins to manifest itself 2 hours after consumption, the pronounced effectiveness appears after 4 hours or more. After 4 months of continuous use, the effect may persist for 48 hours or more.

This drug is the most researched in its group - its effects on the body have been assessed in more than 140,000 people, as a result of which, the relative safety has been clinically proven. According to doctors, these pills are best prescribed to quickly reduce blood pressure, but they can also be used in the long term. It should be noted that thanks to large-scale research of the drug, in the United States it is even approved for use in childhood, but in Russia this is unacceptable.

According to buyers, this is one of the most budgetary funds of the sartan group. Available in concentrations of 40, 80, 160 mg. Among the contraindications are childhood and pregnancy. According to the recommendations of doctors, you should not drink Valsartan while breastfeeding - in studies on rats, the release of the active ingredient in milk has been proven.

The most common side effects are hypotension, dizziness, nausea and diarrhea, weakness, dry persistent cough, decreased immunity, allergic reactions (rash, itching, swelling). It should be noted that most of the above side effects are extremely rare. It is not recommended to prescribe the drug to patients who use diuretics, heparin, lithium carbonate. The tablets are taken once or twice a day, the maximum dose is 320 mg per day, divided by 2 times.

In 2018, when conducting regular studies, the presence of carcinogenic substances in tablets produced by the People's Republic of China was discovered. In Russia, during this period, a large-scale campaign was carried out to withdraw these drugs from circulation. The following year, the content of similar components was discovered in the tablets of the Japanese company Pfizer. There are a large number of Valsartan trade names - Valsakor, Diovan, Nortivan, Valz, Sartavel, etc. The average price of a package, depending on the manufacturer, is 200 rubles or more.

• proven safety;
• pronounced therapeutic effect;
• a large number of trade names, thanks to which you can purchase a blister with the best price-quality ratio, while you can find out how much a particular name costs via the Internet;
• unlike analogs, it can be used in childhood;
• attached at any pharmacy.

• the price of goods from the best manufacturers differs several times from that at which Russian products are sold, which is why most patients are forced to buy a poor-quality Russian analogue;
• some tablets of this group have been found to have carcinogenic components.

Non-phenyl tetrazole derivatives

Eprosartan

The effect of the drug after a single use occurs after two hours and lasts throughout the day. With prolonged use (2 weeks or more), a persistent therapeutic effect is manifested, while the heart rate does not change. Compared with ACE inhibitors, such side effects as persistent dry cough are much less common. The incidence of this phenomenon is 1.5%.

Doctors note a high connection with blood proteins (up to 98%), while the concentration of the substance is maintained at this level throughout the entire period of admission, regardless of the patient's gender and age. The drug is excreted through feces (90%) and kidneys (7%) unchanged, does not accumulate in the body. No dose adjustment is required for elderly patients, as well as those with renal failure.

With regard to Eprosartan, two large-scale studies were carried out on patients with type 2 diabetes, as well as cardiovascular and cerebrovascular diseases. Based on the results of these studies, the following conclusions were made: the drug is recommended to be prescribed separately from ACE inhibitors and ARA II, as the risk of hyperkalemia, arterial hypertension, and acute kidney damage increases. It is also not recommended to prescribe Eprosartan together with Aliskiren, since not only side effects were noted, but also the risk of death increased.

Of the contraindications to the use of Eprosartan, one can single out pregnancy, breastfeeding, serious disorders in the renal system, childhood, simultaneous administration together with the drugs that were mentioned above. Side effects: headache, problems with the functioning of the gastrointestinal tract, rhinitis, allergic skin reactions, renal failure in patients with disorders in the work of this system. There are practically no data on the consequences of an overdose. There is only information that one of the patients had a vascular collapse after taking a large dose, but after treatment he completely recovered. Other consequences include a serious drop in blood pressure.

The trade names of the product are Teveten, Eprosartan mesylate and Naviten. The average price of a package is 1,000 rubles. In addition to arterial hypertension, other indications for the use of the drug are the following diseases: hypertension (especially with an increase in the myocardium), as a prophylactic agent for the likelihood of a heart attack and stroke, heart failure, pathologies in the renal system, atherosclerotic and vascular disorders.

• there is no side effect often found in analogues of this drug - dry persistent cough;
• proved to be good when prescribed to patients after a heart attack - the survival rate is significantly increased;
• in case of an overdose, there are no serious health problems;
• side effects are rare;
• to correct the pressure, it is enough to use one tablet per day.

• high price;
• some patients noted in the first days of taking the drug disorders of the nervous system (dizziness, weakness, nausea), which can interfere with working with complex mechanisms and driving vehicles.

Latest generation non-biphenyl tetrazole derivatives

The drugs of this group have a number of characteristics that radically distinguish them from their predecessors. When choosing which drug from which company is better to buy, we recommend paying attention to this particular group - they have a minimum of side reactions, and they affect the human body in a complex (they suppress all angiotensin receptors at once).

Unfortunately, only one drug is officially registered in Russia - Telmisartan, all the rest are still outside the law. Therefore, before choosing a particular name on the Internet, it is worth finding out if it is accredited in our country.

Telmisartan

Most often, this drug can be found in pharmacies under the Mikardis trademark. There are also names such as Telzap, Telmista, Telsartan, Pritor, Teseo, etc. In addition to the main active ingredient, the drug also contains the following components: sodium hydroxide, magnesium stearate, povidone K25, etc.

The main purpose is primary or secondary hypertension. The active ingredient blocks angiotensin II receptors, with an increase in dosage, it also regulates the level of sodium and chloride, and diuresis. It has the function of protecting the kidneys, reduces myocardial damage. The tool is able to control both types of blood pressure without affecting the heart rate.

Studies have shown that the substance is well absorbed through the gastrointestinal tract system, while it is excreted from the body slowly, for more than a day, most of it with feces (80%), the rest with urine.

Blood pressure begins to decrease 3 hours after taking the pill, the effect lasts for 3 hours or more, and becomes stable a month or two after the start of use. After the patient stops taking pills, the indicators smoothly return to their original values ​​within a few days. There is no withdrawal syndrome. The effectiveness of the drug in young and old people does not differ. This medication is often prescribed to patients over 55 years of age who have cardiovascular disorders, which helps to reduce mortality, as well as hospitalizations associated with heart attacks and strokes.

Unlike most medicines, the list of contraindications is small - pregnancy, breastfeeding, hypersensitivity to any component of the drug, severe liver and kidney dysfunction. There are restrictions on the use of the drug by children, since large-scale studies of the effect on their body have not been conducted. It is also worth prescribing Telmisartan with caution to persons with obstructive cardiomyopathy, stenosis of heart valves, chronic heart failure, disorders in the functioning of the kidneys and liver in the initial stage, reduced volume of circulating blood, when belonging to the Negroid race.

Telmisartan must be drunk once a day, regardless of food intake. Depending on the disease, the initial dose is 20, 40, or 80 mg. It should be borne in mind that the required therapeutic effect is achieved 4-8 weeks after the start of administration, therefore, dose adjustment at the initial stages of use is not made. For patients with renal failure, the maximum dosage is 40 mg per day.

The most common side effects are weakness, increased fatigue, allergic manifestations in the form of skin rash and itching, excessive decrease in blood pressure, and infections of the genitourinary and respiratory system. There have been no confirmed cases of overdose. The following conditions are thought to occur: extreme drop in blood pressure, tachycardia, bradycardia, weakness, and dizziness. In case of an overdose, you should immediately seek help from a medical institution, provide peace and fresh air for the patient. If a short amount of time has passed after taking the medicine, it is recommended to induce vomiting and rinse the stomach, otherwise the use of specific medications is necessary.

When using Telmisartan, patients are advised to drive with caution and use complex equipment, as it can cause drowsiness and dizziness.

In pharmacies, the product is sold only by prescription, depending on the number of tablets and dosage, the average price of a pack is 300 - 400 rubles.

• has a small number of side effects and contraindications;
• does not affect the heart rate, so that the drug can be prescribed to patients from risk groups for relevant diseases;
• well tolerated by most patients;
• budget price.

• some patients report difficulties finding a drug over the counter.

Conclusion

When choosing which drug of the sartan group is better to buy, you should not prescribe it yourself if you do not have specialized medical education. It must be remembered that these are prescription drugs that have an impressive list of side effects and contraindications, and, if self-medicated, can harm human health. We hope that our article will help you make the right choice!